Herein, despite the YPF-peSDF ability to modulate inflammation (by elevating PELF IL-6 and small intestine IL-10 and reducing small intestine TNFα generation and leukocyte accumulation in the peritoneum) and oxidative stress (by attenuating PELF LPO and TAC levels), the fibre was not able to protect against sepsis-induced mortality and hypothermia and, on the contrary, accelerated mortality and exacerbated hypothermia in septic mice. The gene discussed is IL10; the disease is Sepsis.