We aimed in this research to investigate how a compound (KSK-94) with the strongest affinity at the histamine H3 receptor from this group, and significant binding to the sigma-2 receptor, which significantly reduced the development of obesity and selected metabolic disorders [32], influenced adipose tissue—the number and size of adipocytes and released factors (adipokines, factors involved in inflammation) in this model of developing obesity. The gene discussed is HRH3; the disease is metabolic disease.