As for the Kir6.2 subunit, gain-of-function (GOF) mutations (KCNJ11/ABCC8) in the Kir6.2 subunits of pancreatic KATP channels have been identified as the most common cause of human neonatal diabetes mellitus, nDM [53]. This evidence concerns the gene KCNJ11 and neonatal diabetes mellitus.