Among the oxidative stress and inflammation markers (Table 2 and Figure 2) evaluated in this study, supplementation with curcumin + piperine for 3 months proved effective in significantly increasing SOD levels compared to the placebo group after adjusting for sex, age, and type of IBD (4346.9 ± 879.0 vs. 3614.5 ± 731.5; p = 0.02; CI95%: 102.262–1528.186). This evidence concerns the gene SOD1 and inflammatory bowel disease.