CXCL10 and Insulin resistance: Adipose expression of CXCL10 is upregulated in metabolic conditions, such as diabesity, which plays a critical role in adipose tissue inflammation, insulin resistance, and metabolic dysfunction through changes that involve cellular extravasation into adipose tissue and the activation of major immune effector cells such as monocytes/macrophages, T-cells, dendritic cells, and NK cells [19].