LRP1 and Alzheimer disease: Moreover, knockdown of hepatic LRP1 expression in APPswe/PSEN1dE9 mice was shown to not only lead to higher concentration of Aβ and amyloid plaques in the brain but it also worsened the behavioral decline and increased other AD-related pathological features, including neurodegeneration, neuroinflammation and τ hyperphosphorylation [180].