INS and Hypoglycemia: Nonetheless, “fully closed-loop” automated insulin delivery system development remains an arduous goal and is hindered by the non-linear relationship between subcutaneous insulin administration and postprandial glucose due to unforeseeable trends in glucose absorption following meals characterized by post-prandial hyperglycemic excursions and tardive post-prandial hypoglycemia due to the delay in the insulin action of currently available rapid-acting insulin analogues [58].