We then evaluated the cytotoxic potency and efficacy of the 8F2-SG3199 and R20-SG3199 in three NB cells lines (SKNAS, SKNBE2, and CHP212) expressing LGR5 at high levels and CHP212-LGR5KO cells (Figure 1C,D). This evidence concerns the gene LGR5 and neuroblastoma.