FLT1 and neoplasm: VGB3 could interfere with VEGF binding to VEGFR-1/2 and inhibit angiogenesis and tumor growth via downregulation of the PI3K/AKT/mTOR and PLCΥ/ERK1/2 pathways in human umbilical vein endothelial cells (HUVECs) and 4T1 cells, as well as inducing apoptosis through both intrinsic and extrinsic pathways [37].