SHP2, encoded by PTP1B1, is another PTP that has been extensively investigated in the context of cancer development, mainly because of its facilitation of signaling pathways, such as RAS/RAF/ERK, PI3K/AKT, JAK/STAT, and RTKs, across a variety of cancers [108,109,110,111,112,113,114,115,116,117,118,119]. This evidence concerns the gene AKT1 and cancer.