BIRC5 and cancer: This system was constructed by Li et al. (2022) for the co-delivery of DOX and CRISPR/Cas9 plasmid expressing survivin (Survivin CRISPR/Cas9-expressing plasmid -sgSurvivin pDNA) or plasmid expressing shRNA survivin (Survivin shRNA-expressing plasmid, iSur pDNA) to reduce survivin protein expression, involved in inhibiting cancer cell apoptosis.