NT5E and neoplasm: CL-PEG-TAT NPs (CLP-TAT NPs) were evaluated for siRNA transport targeting tumor-promoting factors (CD73 and IL-6), revealing enhanced uptake of CLP-TAT-siRNA NPs in vitro, exceeding 73% in breast and colorectal cancer cells (4T1 and CT26), a significant increase compared to NPs devoid of TAT addition (23%).