Generally, the titers of the specific IgM and IgG antibodies are determined as part of the organisms’ humoral immune responses, where IgMs are usually ascending in an acute infection, the elevation of both IgM and IgG simultaneously indicate an active infection (acute, reactivated infection or reinfection) and the detection of specific IgGs alone signals a chronic or latent infection [11]. Here, CD40LG is linked to disease arising from reactivation of latent virus.