In a study conducted on 300 Iranian women who were at risk of recurrent pregnancy loss and a control group comprising 300 healthy women pregnancies with successful delivery, an analysis of polymorphisms and the interleukins IL-10, IL-18, and IL-33 found that higher frequencies of interleukin IL-33 are associated with the risk of suffering miscarriage [13]. The gene discussed is IL33; the disease is spontaneous abortion.