Conversely, a retrospective study including 61 pediatric patients (mean age 10.3 years; >75% affected by hematological disease, 50% of whom were undergoing HCT) found by multivariate analysis that a CRP level < 110 mg/L was an independent predictor of low voriconazole Cmin < 1.0 mg/L (p = 0.045) [28]. Here, CRP is linked to hematologic disorder.