The exception was the acsl1 gene, a key lipid metabolism enzyme that catalyzes the conversion of long-chain fatty acids to their active form, acyl-CoAs; thus, it is suppressed expression in HD fish would serve to maintain monocytes and macrophages responsiveness following exposure to pro-inflammatory molecules produced after infection with gram-negative pathogens at a low threshold level [117]. The gene discussed is ACSL1; the disease is infection.