Several studies focusing on the viral mechanisms of SARS-CoV-2 infection have pointed to the importance of the surface receptor for the viral spike 1 protein (S1) of the angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine-2 (TMPRSS2) receptor in COVID-19 [8]. The gene discussed is TMPRSS2; the disease is COVID-19.