Although CD8+ T cells are capable of recognizing and eliminating target cells expressing C. trachomatis proteins Cap1 and CrpA, as well as secreting IFNγ to resolve Chlamydia infection, studies have demonstrated that the absence of CD8 or perforin-deficient mice does not affect the clearance rate of the infection compared to wild-type mice, indicating their nonessential role in clearing Chlamydia in mice [113]. Here, CD8A is linked to chlamydia infectious disease.