Additionally, several complementary mechanisms were identified such as the modulation of caspase-3 and -7 activity, which triggered apoptosis in HepG2 and SMMC-7721 hepatocarcinoma cells [60], A549 and NCI-H1703 non-small cell lung cancer cells [61], and u937 leukemia cells [62]. The gene discussed is CASP3; the disease is non-small cell lung carcinoma.