AKT1 and non-small cell lung carcinoma: AS-IV [122] induces apoptosis in NSCLC and lung adenocarcinoma cells by inhibiting the Akt/Glycogen synthase kinase 3β (GSK-3β)/β-catenin signaling pathway, inhibiting Bcl-2, and promoting the expression of Cyt C, Omi, Bax, and caspase3.