We also presented arguments that DNA repair in migraine might be compromised because transient receptor potential melastatin 2 (TRPM2) might link DNA single-strand break repair proteins, including poly(ADP-ribose) polymerase 1 (PARP1), XRCC1, and DNA topoisomerases, with migraine-related neuroinflammation [37]. This evidence concerns the gene XRCC1 and migraine disorder.