TRPA1 and migraine disorder: Marone et al. showed that TRPA1 and NDPH oxidase 1/2 (NOX1/2) supported an autocrine pathway within the neuronal cell bodies of trigeminal ganglia to sensitize meningeal nociceptors and second-order trigeminal neurons to provoke periorbital allodynia and could be important for migraine-like headaches induced by GTN [98].