AKT1 and malignant colon neoplasm: For instance, the saponins from edible spears of wild asparagus (triguero Huétor-Tájar, HT, landrace) inhibit AKT, p70S6K, and ERK signaling and induce apoptosis through G0/G1 cell cycle arrest in human colon cancer HCT-116 cells [25].