MAPT and Alzheimer disease: Here, we report: (1) molecular docking studies of ISAS and NIPZ to human Tau; (2) assessment of logP; (3) synthesis of ISAS, NIPZ, and analogs; (4) measurement of binding affinity of the analogs for Tau using the postmortem AD brain; (5) radiosynthesis of [125I]ISAS and [125I]NIPZ; (6) autoradiographic studies of [125I]ISAS and [125I]NIPZ in postmortem AD brain slices.