G6PC1 and type 2 diabetes mellitus: Additionally, the expressions of histone deacetylase (HDAC) 1 and 2 and glucose 6-phosphatase (G6Pase) were suppressed, while the expression of histone acetyltransferase 1 (HAT1) was increased, suggesting that enzymes involved in epigenetics may play a role in the maintaining glycemic control in T2DM, particularly with OA treatment [79,80].