OA activates apoptosis in the hepatocellular carcinoma (HCC) cells SMMC-7721 and BEL-7404 by altering the Bax/Bcl2 balance, inducing the release of cytochrome-c and activating caspase-9 and caspase-3 [106,107]. The gene discussed is CASP9; the disease is hepatocellular carcinoma.