Sukumar et al. created mouse models with endothelial-specific insulin resistance to show impairments in endothelium-dependent vasodilation, the overproduction of superoxide, and overexpression of NOX2 in pulmonary ECs isolated from the aorta and lungs of transgenic mice; subsequently, OS and vascular endothelial dysfunction were inhibited by the knockdown of siRNA against NOX2 [34]. Here, CYBB is linked to Insulin resistance.