Zhou et al. found out that notopterol effectively decreased the concentrations of cytokines (iNOS, TNF-α, IL-6, and IL-β) and suppressed the activity of the STAT3/NF-κB signaling pathway in brain tissues surrounding the tumor and in a microglial cell line (BV2 cells) treated with GL261 conditioned media (GCM) [86]. Here, STAT3 is linked to neoplasm.