IL1B and hepatocellular carcinoma: To analyze the possible contribution of HSC senescence and HCC development, Yoshimoto and colleagues used a mice model knock-out for the gene of IL-1 beta, a cytokine associated with both cancerogenesis and tumor suppression since it acts on the tumor microenvironment (TME) [32,34,35], and observed a parallel reduction in activated HSCs and the number of liver tumors [32,35].