Of note, Manuka honey at 2.5–5.0% (w/v) also provoked a significant 75% reduction (p < 0.05) in the proliferation of human H2110 non-small cell lung cancer and PANC1 pancreatic cancer cells that express the aromatase enzyme needed for local estrogen biosynthesis as well as estrogen receptors (Supplementary Figure S1) [33]. This evidence concerns the gene ESR1 and familial pancreatic carcinoma.