Oral administration of P. gingivalis in mice, mimicking the effects of periodontitis, altered their gut microbiome, caused dendotoxaemia and increased macrophage infiltration into adipose tissue, as well as an inflammatory response in the liver by increasing the pro-inflammatory cytokines TNF-α, IL-6, Fitm2 and Plin2, which, in turn, may indicate a link between oral infection and bacterial ingestion and transfer of the gut microbiota to the liver. This evidence concerns the gene TNF and periodontitis.