After 6 months on the test diets, those with the T allele of GIPR (rs2287019) assigned to the low-fat diet lost more weight (p = 0.06) and had greater decreases in fasting glucose (p = 0.006), fasting insulin (p = 0.03), and insulin resistance measured by HOMA-IR (p = 0.01) than those eating the high-fat diet where there were no significant genotype effects on changes weight, insulin levels or insulin resistance [13]. This evidence concerns the gene GIPR and Insulin resistance.