To determine whether CML accumulation in hepatic steatosis is implicated in the induction of lipid metabolism, we evaluated sterol regulatory element binding protein (SREBP)-1c, carbohydrate response element binding protein (ChREBP), fatty acid synthase (FAS), and stearoyl-CoA desaturase1 (SCD1) proteins expression in the liver. The gene discussed is SREBF1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.