A recent meta-analysis confirmed how the daily use of saffron, in different forms, is able to reduce OS in patients with depression, highlighting a concomitant increase in the activity of antioxidant enzymes (such as superoxide dismutase-SOD, catalase-CAT and glutathione peroxidase), activities that are usually altered in patients with depression [51]. Here, SOD1 is linked to depressive symptom measurement.