TGM2 and Cowden disease: Over the last 20 years, highly predictive serological tests, including antibodies to endomysium (EmA) and TG2 (anti-TG2) [8], and deamidated gliadin peptide (DGP) reduced diagnostic delay and improved CD detection, thus identifying patients with very different symptoms from classical (e.g., diarrhea) to unexpected ones (e.g., extra-intestinal manifestations) or even asymptomatic [7].