IL6 and rheumatoid arthritis: Interestingly, most patients with rheumatoid arthritis or spondyloarthritis have found their symptoms relieved after fasting during Ramadan, which may be related to the downregulation of the expression of the pro-inflammatory factors c-reactive protein (CRP), interleukin-1β (IL1β), and interleukin-6 (IL6) [21].