NFKB1 and obesity due to melanocortin 4 receptor deficiency: Both effects lead to a reduction in the proinflammatory and pro-oxidant state of adipose tissue, lowering the production of harmful adipokines (Res, Vis, and Ap) [59,60,61,62,63], and an elevation in protective adipokines, which is associated with the inhibition of inflammatory mediators related to the NF-κB pathway and an increase in the nuclear translocation of Nrf2 (redox control), endothelial protection, and glucose homeostasis in individuals with obesity and T2DM [18,64,65].