Consistent with TUNEL staining, treatment with finasteride and ACE (AGEprost®) increased the ratio of Bax, a proapoptotic protein, to Bcl-2, an anti-apoptotic protein, in the prostate tissue relative to that in the BPH group (Figure 6B, p < 0.01). The gene discussed is BCL2; the disease is benign prostatic hyperplasia.