LEP and breast cancer: In obese postmenopausal BC survivors, 16 weeks of supervised combined aerobic and resistance exercise sessions three times per week elicited a decrease in the number of M1 macrophages and an increase in the number of M2 macrophages in adipose tissue, accompanied by higher plasma adiponectin levels and lower plasma CRP, leptin, IL-6, and IL-8 compared to baseline as well as to the control group [230].