IGF1 and breast cancer: The RCT [NCT03045289] demonstrated that a whole-food, plant-based diet could lead to beneficial outcomes in women with metastatic BC, particularly in terms of weight management (significant weight loss), cardiometabolic health (evidenced by reductions in total and LDL cholesterol, lower blood pressure, and improved glycemic control), and hormonal balance (reduced levels of IGF1 and alterations in estrogen levels) [116].