TNF and breast cancer: Conversely, in a trial conducted in survivors of triple-negative BC with BMI > 25, moderate-intensity aerobic exercise (150 min per week for 12 weeks) did not change serum adiponectin, leptin, insulin, CRP, IL-6, or TNF-α, despite a loss of body fat, although serum leptin and adiponectin and their ratio significantly correlated with BMI [241].