Given the paramount importance of insulin receptors and compensatory hyperinsulinemia in the induction of androgen excess in PCOS women, low-carbohydrate diets reducing the levels of glucose, insulin, IGF-1, and insulin-like growth factor-binding protein 1 (IGFBP1) may improve hyperandrogenism-related symptoms [18,19]. The gene discussed is IGFBP1; the disease is hyperinsulinism.