Additionally, Figure 2C shows that KD induced the IL-6 and p-JNK signaling pathways that are associated with glucose intolerance and HS, while both neutralization of IL-6 and inhibition of the p-JNK pathway were effective in reversing KD-provoked glucose intolerance and alleviating HIR [84]. The gene discussed is MAPK8; the disease is Glucose intolerance.