IL6 and obesity due to melanocortin 4 receptor deficiency: In addition, while an alteration of the IL-6/NA feedback and impairment in the NA-mediated regulation of cytokines released by peritoneal macrophages are involved in genetic-induced obesity [58,66], the dysregulation between the IL-1β-mediated inflammatory response and corticosterone-mediated stress response is involved in the high-fat diet-induced obesity.