INS and diabetes mellitus: Table S4 shows that among the individuals with known diabetes (n = 311), moderate weight loss was a strong predictor for reduced likelihood of using insulin (95% CI, OR = 0.34 (0.15–0.81), p = 0.015), other diabetes medication use (OR = 0.47 (0.23–0.97), p = 0.040), and improved glycemic control (OR = 0.28 (0.13–0.61), p = 0.001).