We assessed the correlation between both severity scores, SOFA and APACHE II, and the PD-1/PD-L1 axis, in order to provide an extended picture of the organ dysfunction and immunological status of sepsis and septic shock patients, and we found a statistically significant positive correlation between PD-L1 and the severity scores on day 1 in non-survivor patients. Here, PDCD1 is linked to Sepsis.