MCs produce multiple angiogenic factors including proteases (chymase and tryptase), basic fibroblast growth factor (bFGF), IL-8, transforming growth factor (TGF-β), TNF-α and vascular endothelial growth factor (VEGF), which stimulate neovascularization [90], a crucial process for supplying nutrients to the tumor and facilitating tumor promotion [91]. The gene discussed is TNF; the disease is neoplasm.