Notably, preliminary data from our laboratory show that FASN knockdown does not trigger the downregulation of SKP2 and the upregulation of p27KIP1 in colorectal cancer and glioblastoma cell lines (Cigliano et al., unpublished observation), suggesting that the existence of a FASN/SKP2/p27KIP1 axis might be a tumor-specific feature. This evidence concerns the gene CDKN1B and colorectal cancer.