The most common are found in von Hippel–Lindau disease (VHL gene causing clear cell renal cell carcinoma), BRCA1 gene protein mutation (BAP1 gene causing clear cell renal cell carcinoma), papillary hereditary renal carcinoma (MET gene with production of papillary renal carcinoma type 1), hereditary leiomyomatosis (FH gene with production of papillary renal carcinoma type 2). The gene discussed is FH; the disease is hereditary leiomyomatosis and renal cell cancer.