EDN1 and open-angle glaucoma: The sensitivity analysis confirmed the results showing higher aqueous humor ET-1 levels for POAG patients by a pooled mean difference of 1.47 pg/mL ET-1 (95% CI: 1.04–1.90, p = 0.03), after funnel plot evaluation and two outlier studies removals, with moderate heterogeneity among studies (I2 = 73%, p = 0 < 0.01) (Figure 6, Panel B).