Furthermore, the oligosaccharide composition of Descurainiae sophia used alongside Lepidium apetalum, as used by Ting Li Zi in EATM clinical practice, decreased serum levels of troponin I, brain natriuretic peptide, angiotensin II, aldosterone, renin, and arginine vasopressin and downregulated renal aquaporin-2 expression in Sprague Dawley rats of the doxorubicin-induced HF model, confirming its cardioprotective effect against HF [53]. This evidence concerns the gene REN and hydrops fetalis.