Cano et al., in a study involving 26 patients treated with insulin for diabetes associated with WS and 56 patients diagnosed with type 1 DM, showed that HbA1C values were much lower in the WS patient group (7.72 ± 0.21%) compared to HbA1C 8.99 ± 0.25% in patients with type 1 DM; insulin doses were also much lower in WS patients (0.71 ± 0.07 IU/kg/day) compared to 0.88 ± 0.04 IU/kg/day in patients with type 1 DM [49]. Here, INS is linked to diabetes mellitus.