WFS1 and Low-frequency sensorineural hearing impairment: Pathogenic variants of the WFS1 gene are most commonly associated with the autosomal recessive form of Wolfram syndrome (WFS1), autosomal dominant-Wolfram-like syndrome (WFSL, MIM #614296), and WFS1-related low-frequency sensorineural hearing loss (LFSNHL, DFNA6/14/38, and MIM #600965).