Compared to the HPLB subgroup, the HPHB subgroup had higher concentrations of BNP, uric acid, ALT, and total bilirubin and a higher incidence of diabetes mellitus but lower LVEF, BMI, and eGFR, reduced levels of total cholesterol and albumin, and lower prevalence of males and coronary artery disease. The gene discussed is NPPB; the disease is diabetes mellitus.