A study by Zhang et al. also demonstrated that in rats treated with insulin and/or human chorionic gonadotropin (hCG), there was a PPARα/β-Srebp1/2-Acc1 axis-mediated dysregulation between de novo lipogenesis and mitochondrial β-oxidation associated with hepatic steatosis, with hCG-induced hyperandrogenic rats exhibiting exacerbated hepatic inflammation [63]. This evidence concerns the gene INS and fatty liver disease.