TNF and polycystic ovary syndrome: Indeed, in a rat model of hyperandrogenic PCOS, increased levels of serum inflammatory markers such as TNF-α and IL-1β, increased urocortin-1 mRNA expression along with the formation of a hepatic necrotic lesion, clearly demonstrating the onset of inflammation in the hyperandrogenic state of PCOS, indicating that it can lead to steatosis by altering the levels of hepatic inflammatory mediators and stress-related proteins [59].