INS and Insulin resistance: Additionally, their study concluded that due to the fact that more pronounced liver steatosis, inflammatory response, and hepatocellular damage was observed in insulin- and hCG-induced PCOS-like rats, MASLD seen in individuals with PCOS is dependent on hyperandrogenism and insulin resistance, while hyperinsulinemia, hyperandrogenemia, and insulin resistance modify liver metabolism of lipids, hepatic function, and inflammatory response, with the effects of the individual conditions being distinct from each other.