INS and polycystic ovary syndrome: Similarly, another study reported significant improvements in plasma glucose and serum insulin levels in women with PCOS following an 8-week supplementation regimen with L. casei, L. acidophilus, L. rhamnosus, L. bulgaricus, B. breve, B. longum, and Streptococcus thermophiles, while Rashad et al. found that probiotic supplementation (L. delbruekii and L. fermentum) over 12 weeks led to a significant decrease of HOMA-IR levels and further improved the lipid profile [84,85].