PHD2 ablation by subretinal injections of AAV8:U6-gRNAs_PHD2 (i.e., prolyl hydroxylase domain 2), targeting rod specific aerobic glycolysis via PHD-HIF (i.e., hypoxia-inducible factor) reprogramming, rescued degeneration in both recessive and dominant RP mouse models without inducing toxicity. The gene discussed is EGLN1; the disease is retinitis pigmentosa 1.